The show, tentatively titled Lovely Button after Killen's Twitter username (@LovelyButton), will feature Danica McKellar, best known as Winnie Cooper from The Wonder Years, as a woman who tweets about peanut butter and planning her wedding.
"We think Sarah's 33 tweets will make a fascinating basis for a sitcom," said NBC CEO Jeff Zucker. "She's clearly got what 18- to 49-year-old men are looking for, whatever that is."
The sitcom was originally planned to revolve around the changes in the main character's life after Conan O'Brien follows her on Twitter, but NBC had to scrap that angle after being threatened by O'Brien's attorneys.
"Apparently there's still some resentment there," admitted Zucker, who removed O'Brien from The Tonight Show after seven months to replace him with former host Jay Leno. "We sent (NBC executive) Dick Ebersol to his house to try to talk to him, but Max Weinberg came out and hit him with a timpani."
Some analysts say NBC is scrambling to compete with rival CBS, which recently announced a sitcom starring William Shatner based on the Twitter feed S--t My Dad Says, tentatively titled Oh, The Things My Dad Says!