"The world is full of cruel, cold-hearted people who would do such a thing," Palin said in an appearance on Fox News Channel's The O'Reilly Factor. "To show a likeable, well-adjusted character with Down syndrome on TV ... That's just wrong."
She also said she took the show as a personal affront to her and her family when she saw a rerun recently on ABC Family.
"The America I know and love is not one in which my family would have to see a show like that, which was clearly meant at a swipe at my retarded baby, Trig," she said. "Um ... and when I say retarded, like Rush Limbaugh I mean that in a satiric kinda way."
When O'Reilly asked her how she would define the term "satiric," she paused for about 30 seconds and then said, "All of 'em."
Palin's complaint comes after she and her family made an uproar over the Fox TV series Family Guy, which featured a similarly well-adjusted character with Down syndrome, voiced by an actress with the condition.
"Dude, I can't believe that's the one they decided to get worked up about," said Family Guy creator Seth MacFarlane, who noted that in one episode during the campaign, Palin and her entire family were portrayed as "back-woods troglodytic mouth-breathers."
"One episode of 60 Minutes, I mean," he clarified, cracking himself up and high-fiving the members of his writing staff, who were gathered to work on an upcoming episode entitled Stewie Says Something Inappropriate.
"And you didn't hear Democrats complaining when we did that episode where Glen Quagmire accidentally has sex with Bill Clinton," MacFarlane noted.